Why does tirzepatide cause diarrhea?

Tirzepatide slows gastric emptying and acts on GLP-1 and GIP receptors that regulate digestion, and gastrointestinal effects, including diarrhea, nausea, and constipation, are among the most commonly reported side effects across its trials. This is a class effect shared with other GLP-1 based drugs like semaglutide, driven by the same digestive slowing mechanism that also contributes to reduced appetite and, ultimately, weight loss.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.