Why does tirzepatide cause diarrhea?

Tirzepatide slows how fast the stomach empties. It also acts on GLP-1 and GIP receptors that control digestion. Stomach and gut problems, including diarrhea, nausea, and constipation, are among the most common side effects across its studies. Other GLP-1 drugs like semaglutide share this. It comes from the same slowing of digestion that also helps cut appetite and, in the end, weight.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.