Why does semaglutide stop working?

This site does not hold a citation that measures when semaglutide stops working for one person, or that names a tolerance clock. What it holds is how long the trials ran: STEP 1 to 68 weeks, OASIS 4 to 64 weeks, STEP UP to 72 weeks, SELECT for cardiovascular events over a mean 39.8 months in 17,604 adults, and evoke to 104 weeks for Alzheimer's, where the drug did not slow decline. An average weight-loss curve that flattens inside a trial window is not the same finding as the drug failing. Common non-drug reasons a person might see less change include missed doses, a change in food intake, and a research-chemical vial that is not the labeled pen. Those are clinical questions, not a date this FAQ will invent. Talk with the clinician who prescribed it. Full record at /compounds/semaglutide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.