Why does semaglutide stop working?

This site does not hold a citation that measures when semaglutide stops working for one person, or that names a point where the body gets used to it. What it holds is how long the studies ran: STEP 1 to 68 weeks, OASIS 4 to 64 weeks, STEP UP to 72 weeks, SELECT for heart events over about 39.8 months on average in 17,604 adults, and evoke to 104 weeks for Alzheimer's, where the drug did not slow decline. An average weight-loss curve that levels off during a study is not the same as the drug failing. Common reasons, not about the drug, that a person might see less change include missed doses, a change in food intake, and a research-chemical vial that is not the labeled pen. Those are medical questions, not a date this FAQ will invent. Talk with the clinician who prescribed it. Full record at /compounds/semaglutide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.