Can semaglutide cause depression?

This is a real question researchers have looked at, given how the brain's appetite and mood systems overlap, and the picture from large trials has been reassuring rather than alarming: this site's citation review for semaglutide, covering over 17,000 participants, did not identify depression as a primary trial finding. Anyone with a history of mood disorders starting a GLP-1 drug should discuss it directly with their prescriber rather than relying on a general answer.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.