Can semaglutide cause depression?

Researchers have looked at this, since the brain's appetite and mood systems overlap. So far, the picture from large studies is reassuring, not alarming. This site's review of semaglutide studies, covering over 17,000 people, did not find depression as a main result. Anyone with a history of mood problems who starts a GLP-1 drug should talk about it directly with their prescriber, and not rely on a general answer.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.