How does retatrutide work?
It switches on three receptors at once: GLP-1, GIP, and glucagon (three gut and blood-sugar hormones). That is one more than tirzepatide and two more than semaglutide. The extra glucagon action is thought to make the body burn more energy and burn more fat in the liver, on top of the appetite-cutting effect of the other two. Researchers think that explains why its studies have reported the biggest weight loss of any drug in this family so far.
Studies in people from the compound pages this answer belongs to
- Retatrutide
- Triple-Hormone-Receptor Agonist Retatrutide for Obesity: A Phase 2 Trial 2023 PMID 37366315
- Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial 2024 PMID 38858523
- A Master Protocol to Investigate the Efficacy and Safety of LY3437943 Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight (TRIUMPH-1) 2026 NCT05929066
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.