How does 5-Amino-1MQ work?

5-Amino-1MQ is a small molecule, not a peptide. This site's profile says it inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in fat-cell energy metabolism and NAD-related pathways. Half-life is listed as short. Molecular weight is 159.2 daltons. This site's review found two citations, neither of them human. It is not FDA approved. Animal citations on that page report that silencing NNMT in adipose tissue and liver protected mice from diet-induced obesity, and that 5-amino-1MQ series inhibitors reduced body weight and fat mass in diet-induced obese mice. Those animal findings do not transfer into a counted human mechanism. This FAQ does not invent a human mechanism. Full record at /compounds/5-amino-1mq.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.