How does GHRP-6 work?
GHRP-6 is an early six-amino-acid peptide. It switches on the ghrelin receptor, GHS-R1a, to release growth hormone. It also raises appetite through the same receptor ghrelin uses for hunger. This site's profile says the body clears half of it in about 15 to 60 minutes. Its molecular weight is 873.0 daltons. This site's review found no human trial citations for it. The receptor itself was discovered in 1996 as the target of GHRP-6 and similar drugs. The 1991 Bowers paper and the 1998 comparison with ipamorelin are animal and cell work. They found it acts on both the brain and the pituitary gland, and releases about as much growth hormone as ipamorelin. But GHRP-6 was less selective and more likely to raise cortisol, prolactin, and appetite. Those animal findings do not transfer into a counted human outcome. It is not an approved drug. This FAQ does not invent a human mechanism. Full record at /compounds/ghrp-6.
Studies in people from the compound pages this answer belongs to
- GHRP-6
- Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. 1990 PMID 2108187
- The growth hormone-releasing activity of a synthetic hexapeptide in normal men and short statured children after oral administration. 1992 PMID 1730807
- Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men. 1993 PMID 7903313
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.