How does MK-677 work?
MK-677, also called ibutamoren, is a small molecule you swallow, not a peptide. It switches on the ghrelin receptor (GHS-R1a), the same docking spot ipamorelin uses, and raises growth hormone and IGF-1. This site's profile says its half-life is about 24 hours. Its molecular weight is 624.8 daltons. A two-year study in 65 adults aged 60 to 81 found growth hormone and IGF-1 rose to young-adult levels. Lean mass went up 1.1 kg, while people on a dummy pill lost 0.5 kg. But strength and function did not improve, and fasting blood sugar and insulin resistance rose. A mid-stage study in 123 people with hip fractures was stopped early over a safety warning sign for heart failure. Raising growth hormone is not the same as a measured fat-loss result. This FAQ does not invent a dose. Full record at /compounds/mk-677.
Studies in people from the compound pages this answer belongs to
- MK-677
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial 2008 PMID 18981485
- MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study 2011 PMID 21067829
- Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man 1997 PMID 9349662
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.