Why is MK-677 not FDA approved?

It completed Phase 3 clinical trials but the studies did not support approval; one well known trial in older adults found it increased growth hormone and IGF-1 as intended but also raised blood glucose and did not improve the physical function outcomes it was tested for. That result, not a lack of testing, is why an orally active compound that reached late stage trials never reached the market.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.