Why is MK-677 not FDA approved?
It finished late-stage studies, but the results did not support approval. One well-known study in older adults found it raised growth hormone and IGF-1 as planned. But it also raised blood sugar and did not improve the physical function it was tested for. That result, not a lack of testing, is why a pill that got to late-stage studies never reached the market.
Every FDA-approved compound in the archive, as a list
Studies in people from the compound pages this answer belongs to
- MK-677
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial 2008 PMID 18981485
- MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study 2011 PMID 21067829
- Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man 1997 PMID 9349662
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.