How does tesamorelin work?
Tesamorelin latches onto the GHRH receptor on the pituitary gland, the same docking spot the body's own growth hormone releasing hormone uses. It sets off a burst of growth hormone, instead of supplying growth hormone as a drug. This site's profile says the body clears half of it in about 26 to 38 minutes. Its molecular weight is 5,135.9 daltons. The approved product, Egrifta, is for HIV-related deep belly fat. In 412 people at 26 weeks, belly fat fell 15.2%, while it rose 5.0% on a dummy shot. Across 806 people pooled, the drug cut deep belly fat by 15.4% more than the dummy shot, with no change in the fat just under the skin. That is a belly-fat result in that group of people, not a general fat-burning finding. This FAQ does not invent a dose. Full record at /compounds/tesamorelin.
Studies in people from the compound pages this answer belongs to
- Tesamorelin
- Metabolic effects of a growth hormone-releasing factor in patients with HIV 2007 PMID 18057338
- Effects of tesamorelin (TH9507) in HIV-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data 2010 PMID 20554713
- Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial 2012 PMID 22869065
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.