How does sermorelin work?
Sermorelin latches onto the GHRH receptor on the pituitary gland. That is the same docking spot the body's own growth hormone releasing hormone uses. It sets off a burst of growth hormone, not a constant rise. The body clears half of it in only about 10 to 20 minutes. So it gives a short signal, not steady hormone levels. That is closer to how the body releases growth hormone in bursts than a shot of growth hormone itself would be.
Studies in people from the compound pages this answer belongs to
- Sermorelin
- Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men 1992 PMID 1379256
- Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group 1996 PMID 8772599
- Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women 1997 PMID 9141536
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.