What is sermorelin?
Sermorelin is a piece of growth hormone releasing hormone (GHRH), the body's signal to make growth hormone. It is the first 29 amino acids of the natural 44 amino acid molecule. That is enough to latch onto the GHRH receptor and tell the pituitary gland to release its own growth hormone. It was FDA approved as Geref, to diagnose and treat growth hormone deficiency, before that product was pulled. Today it is mainly available through compounding pharmacies for off-label use.
Studies in people from the compound pages this answer belongs to
- Sermorelin
- Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men 1992 PMID 1379256
- Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group 1996 PMID 8772599
- Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women 1997 PMID 9141536
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.