What is MK-677?
MK-677, also called ibutamoren, is a small molecule you swallow, not a peptide. It switches on the ghrelin receptor to raise growth hormone and IGF-1 (a growth signal the liver makes). It went through studies for problems like frailty in old age, but it did not win FDA approval after late-stage testing. It is sold as a research chemical. It is often grouped with the peptides because it works through the same receptor.
Studies in people from the compound pages this answer belongs to
- MK-677
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial 2008 PMID 18981485
- MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study 2011 PMID 21067829
- Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man 1997 PMID 9349662
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.