What are the side effects of MK-677?
In its two year study in older adults, MK-677 raised fasting blood sugar and made insulin resistance worse. Lean mass went up, but strength and physical function did not improve. A separate mid-stage study in people with hip fractures was stopped early over a safety warning sign for heart failure, before most of its function measures showed a benefit. Those are the two careful studies in people this site's review found. Both turned up a real safety concern next to a partial result.
Side effects by type of peptide, with the study that measured each one
Studies in people from the compound pages this answer belongs to
- MK-677
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial 2008 PMID 18981485
- MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study 2011 PMID 21067829
- Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man 1997 PMID 9349662
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.