How does IGF-1 LR3 work?
IGF-1 LR3 is a changed version of insulin-like growth factor 1 (a growth signal the liver makes). One amino acid is swapped for arginine and a short piece is added to one end. That makes the proteins that normally grab IGF-1 hold onto it less, so it can stay active longer. This site's profile says it switches on the IGF-1 receptor. Its half-life is about 20 to 30 hours. Its molecular weight is 9,111 daltons. This site's review found no published human trial. The studies on that page are animal work. In rats given a steroid drug (dexamethasone), LR3 IGF-I was about 2.5-fold stronger than natural IGF-I at stopping muscle breakdown. In pigs, four days of it by drip lowered daily weight gain, food intake, growth hormone, and the pigs' own IGF-1. In mice bred to make extra IGF-1 in muscle, the muscles stayed bigger into old age. Those animal findings do not transfer into a counted human muscle result. It is not FDA approved and is banned in sport at all times. This FAQ does not invent a human mechanism. Full record at /compounds/igf-1-lr3.
Studies in people from the compound pages this answer belongs to
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of growth hormone secretagogues. Sermorelin, tesamorelin, ipamorelin, CJC-1295, and the rest of the GHRH and ghrelin receptor family.